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Summary of Clinical Studies
Using Blue light as an Acne Treatment
by Dr. Garrett Crawford, PhD

Study #2

Phototherapy with Blue (415 nm) and Red (660 nm) Light in the Treatment of Acne Vulgaris.

P. Papageorgiou, A. Katsambas and A. Chiu
British Journal of Dermatology (2000) 142: 973-978. (read research paper?)

General

Irradiation of bacterial colonies with visible blue light leads to photo excitation of porphyrins, singlet oxygen production (known as oxygen radicals) and the destruction of bacterial colonies.  Red light stimulates the production of new skin cells at the edges of wounds and may have anti-inflammatory properties, which influence the macrophages and other immune cells. (see the Whelan study). 

Method

This study uses fluorescent tubes coated with metal-halides that enrich the white light with blue light.  A second set of fluorescent tubes generates red light on the white light background.

Treatments were carried every day for 12 weeks, using a device delivered 10x less energy to the skin surface than the Shalita study.

Patients were evaluated at weekly intervals for inflammatory spots, and comedomes.  Some patients were treated with white-light fluorescent tubes as controls.  Benzoyl peroxide treatments were carried out as an alternative treatment for comparison purposes.

Results

Similar results were obtained at twelve weeks compared to the Shalita study.  At the conclusion of the treatment period, the blue- only phototherapy gave ~60% improvement in five weeks, comparable to daily 5% Benzoyl peroxide treatment for 12 weeks.  Patients treated simultaneously with blue and red light experienced a 75% reduction in lesions and marked reduction in inflammation, significantly better than the blue-only treatment or the benzoyl peroxide.  The treatments were far better than phototherapy with intense white light alone.  Adverse effects included mild rash and itching in two patients.

How This Study Relates to the Dermillume Pro1500

This study provides the rationale for improved acne treatment results by including red light at 660 nm in the phototherapy treatment of acne.  The ratio of blue light intensity to red light intensity in this study was 2:1. 

Dermillume Pro1500 is called Precision Light Therapy because the intensities and colors of the light meet the exacting clinical requirements for acne treatment.

Accordingly, the Dermillume Pro1500 is designed to generate 20 mWatt/cm² blue light and 10 mWatt/cm² red light at a treatment distance of 4.5” from the skin.

Intense blue light effectively kills acne bacteria deeper in the skin than topical treatments with non of the side effects that are occasionally observed with antibiotics, retinoic acid, or ACCUTANE.

Other Blue Light Study Summaries - [#1]