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Summary of Clinical Studies
Using Red Light to Promote Skin Regeneration
by Dr. Garrett Crawford, PhD

Study #1

Effect of NASA light-emitting diode irradiation on wound healing.

Whelan HT, et al
(2001) J Clin Laser Med Surg 19: 305-314 [read research paper?]

General

This is a study reported from the laboratory that performed the original NASA red light research. The Whelan laboratory is one of the most important laboratories learning how to apply intense light to difficult wound healing problems.

Method

This study used a LED device delivering only red light at 5 J/cm2. A variety of tissue culture and animal model studies were performed to determine the effect of red light on skin cells.

Results

This research study includes tissue culture studies, animal studies and clinical studies with humans. Several wavelengths and intensities were studied in fibroblast (skin cell) tissue culture. The optimum wavelength for cell proliferation and collagen production was determined to be 660. Near-infrared wavelengths were less effective in producing more cells and ineffective in producing more collagen.

Animal studies indicated that the edges of wounds were the source of increases in two types of skin cells (fibroblasts and keritinocytes) that were stimulated by the red and near-infrared light. These two cell types then move into the wound area to form new skin. Wound healing in the treated animals was accelerated. Accelerated wound healing was accompanied by increased amounts of tissue growth factors (studied in a follow-up paper).

Studies were performed on soldiers who are required to live for long periods in diving chambers and injured in deep diving conditions. Abrasions, bruising and small cuts under these conditions can become serious due to very slow healing rates. Wound healing with near-infrared light showed improvement to near normal conditions.

How This Study Relates to the Dermillume Healing Red

The wavelength and intensity of the red light output is similar for thee device used in this research and for Dermillume Healing red measured at 4.5". The requirements of this research were used to determine the design specifications of Dermillume Healing Red.

Dermillume Pro1500 is called Precision Light Therapy because the intensities and colors of the light meet the exacting clinical requirements.

These studies show that 660 nm red light was the optimum wavelength to accelerate production of new skin cells in damaged skin (fibroblasts and keritinocytes and endothelial cells in broken blood vessels). Skin cells in tissue culture experiments were stimulated to produce much higher levels of collagen and elastin. Both of these proteins are used to construct a web that gives skin its elasticity and structural strength. This study observed improved healing in animal and human wounds treated solely with high intensity red light at 660 nm.

Other studies show that 660 nm activates the skin resident immune system, especially the macrophages. Macrophages clean up bacteria and destroyed tissue; in effect they are the garbage disposal crew.

This medical study is the scientific basis for using red light to improve skin tone, reduce wrinkles and pitting, and to reduce the deposition of excess skin pigments and scaring patterns.

Other Red Light Study Summaries - [#2][#3]
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